Coleus root contains a chemical called forskolin. Last updated on Sep 7, 2020. It is closely related to basil, peppermint, thyme and salvia, but unlike most of these the fibrous roots of coleus is used for medicinal purpose. Media in category "Plectranthus barbatus" The following 48 files are in this category, out of 48 total. Medically reviewed by Drugs.com. Forskolin should be avoided in patients with polycystic kidney disease. For best results, plant the seeds indoors, … In 1962, J.K. Morton noted that fused stamens were more widespread than previously thought, and accordingly merged Coleus into Plectranthus, while maintaining Solenostemon and some other genera as distinct. Oral forskolin performed better than sodium chromoglycate in preventing asthma attacks in children and adults with mild/moderate persistent asthma, while inhaled forskolin was not superior to beclomethasone in lung function improvement. Briq. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. It has aromatic green leaves that grow off erect stems, and can reach heights of 2 feet. [4] Most sources followed Morton in submerging Coleus; some kept Solenostemon distinct, although others submerged it into Plectranthus along with Coleus. It grows in tropical regions of Asia such as Nepal, India, and Thailand. Loài này được (Willd.) This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. mô tả khoa học đầu tiên năm 1897. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Forskolin has been demonstrated to have an angiogenic effect via cAMP-dependent protein kinase pathways.Namkoong 2009, Positive inotropic action has been demonstrated in isolated guinea pig, rabbit, and human heart tissue, and in vivo in cats and dogs. Embryo-related toxicity has been reported. Colforsin has a higher affinity for type 5 AC (myocardial AC), does not appear to cross the blood-brain barrier, and exerts a longer duration of action than forskolin. If direct sunlight touches the plant's leaves, the colors become less brightly colored. Other species that produce root tubers are cultivated for food, including Coleus esculentus, Coleus rotundifolius and Coleus maculosus subsp. The root has been used in traditional Indian medicine for centuries to treat heart disease, lung … The plant is native to subtropical and tropical regions of India and East Africa, grows to a height of 60 cm, and has large, soft leaves. In the 1970s, the plant's cardiovascular activity was investigated, while the discovery that the diterpene forskolin directly activates adenylate cyclase (AC) was also made.Lukhoba 2006, Alasbahi 2010, Seamon 2981 Research is largely limited to the use of radiolabeled forskolin to quantify AC and to investigate analogs of forskolin. The Forskolin extracted from the roots of coleus Forskohlii … Some of the species within the genus are difficult to distinguish, leading to unclear taxonomy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Outside this plant needs total shade or only the most mild morning sunlight.[3]. The relationship among the genera Coleus, Solenostemon and Plectranthus has been confused. Tropicos.org, retrieved June 12, … In ancient Sanskrit texts it is known as Makandi and was said to … Forskolina, ou forscolina, cujo nome deriva do anterior nome binomial da espécie, Coleus forskohlii, é um importante constituinte de Plectranthus barbatus, a única fonte comercialmente significativa daquele … Forskolin (coleus forskohlii) with Asthma and Allergies Forskolin is an effective smooth muscle relaxer, resulting in bronchodilation, decreased airway resistance, increased vital capacity and increased … Forskolin increases cellular levels of a molecule called cyclic … Chú thích Liên kết ngoài. Relaxation of the bronchioles has also been demonstrated in isolated ovine tissue.Alasbahi 2010, Limited single-blinded clinical studies have been conducted with oral and inhaled forskolin in patients with asthma and in healthy volunteers. Adverse events were not reported.Huerta 2010, González-Sánchez 2006 Colforsin has also been evaluated as a bronchodilator in a limited number of studies.Wajima 2002, Wajima 2003, Bauer 1993, Studies in animals have shown various effects of forskolin, including induction of melatonin production in the pineal glands, increased melanin in hair follicles leading to an increase in pigmentation, increased hair growth, and a protective effect against ultraviolet B light (UBV)-induced apoptosis.Alasbahi 2010, Chen 2009, Lekmine 2008, Passeron 2009, Case reports exist showing improvement of psoriatic symptoms and a decrease in erythema in patients with hyperplastic skin disorders.Alasbahi 2010, Oral forskolin has been studied using 10 mg daily over 2 to 6 months.Huerta 2010, González-Sánchez 2006, 250 mg of a 10% forskolin extract twice daily for 12 weeks has been studied.Godard 2005, Henderson 2005, Information regarding safety and efficacy in pregnancy and lactation is lacking. The relationship among the genera Coleus, Solenostemon and Plectranthus has been confused. that formed part of Plectranthus s.l. Coleus is a genus of annual or perennial herbs or shrubs, sometimes succulent, sometimes with a fleshy or tuberous rootstock, found in the Old World tropics and subtropics. Adverse events reported with the use of colforsin (a forskolin derivative) include tachycardia and arrhythmias. In many hormone sensitive systems the hormone itself does not enter the target cell but binds to a receptor and indirectly affects the production of another mo… It has been used for over 3,000 years in Ayurvedic Medicine. Forskolin exhibits cardiovascular properties and may have additive effects with anticoagulants, antihypertensives, and vasodilators. Stimulation of AC is thought to be the mechanism by which forskolin relaxes a variety of smooth muscles; however, forskolin has been found to act through other systems, including glucose transport and ion channels.Seamon 1981, Insel 2003, Alasbahi 2010, Iwatsubo 2003, Wessler 2003, Forskolin has been shown in vitro to inhibit platelet aggregation through AC stimulation, augmenting the effects of prostaglandins.Siegl 1982, Adnot 1982 An inhibitory effect on C-kinase activation in platelets has also been described.Alasbahi 2010, Antithrombotic properties have been demonstrated in experiments in rats, rabbits, and sheep.Alasbahi 2010. Used for allergic conditions such as asthma and eczema, … Coleus forskohlii Examples of in a sentence. Coleus Forskohlii (Plectranthus barbatus) – Attribution: Jurema Oliveira Therapeutic Uses, Benefits and Claims of Coleus Forskohlii Coleus is a not a particularly remarkable plant to look at, yet it has a 3000 … What Is Coleus Forskohlii? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. [5] In the version below, the three genera accepted by Paton et al. Synonyms include Plectranthus forskalaei, Plectranthus forskohlii, Plectranthus kilimandschari, Plectranthus grandis, Coleus forskohlii, Coleus barbatus, and Coleus coerulescens. Dosages of Forskolin Should Be Given As Follows: Oral. Coleus forskohlii = Plectranthus barbatus Coleus rotundifolius = Plectranthus rotundifolius Sanggunian. It has several ethnomedicinal uses, which have been transmitted by word of mouth from generation to … Content of the essential oil depends on location and time of harvesting, and mainly consists of mono- and sesquiterpenes. Adverse events were not reported.Godard 2005 A trial conducted among women at the same dosage found no changes in body fat and concluded that forskolin does not promote weight loss. P. barbatus is a perennial herb in a large genus of mints. The oral median lethal dose in rats has been reported to be more than 2,000 mg/kg body weight.Huerta 2010 The hydroalcoholic extract of the plant has been shown to interfere with embryonic implantation and to delay fetal development.Almeida 2000. [1] Species include:[2], https://en.wikipedia.org/w/index.php?title=Coleus&oldid=984532807, Articles containing potentially dated statements from July 2020, All articles containing potentially dated statements, Creative Commons Attribution-ShareAlike License, This page was last edited on 20 October 2020, at 16:02. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The root is used as medicine. Scientific Name(s): Coleus barbatus, Coleus coerulescens, Coleus forskohlii auct., Plectranthus barbatus Andrews, Plectranthus forskalaei, Plectranthus forskohlii, Plectranthus grandis, Plectranthus kilimandschariCommon Name(s): Adel Inj, Asthma X-5, Ele-max, Forskolin, ForsLean, GlucoLean, HL-362, Indian coleus, Interex, Makandi, Mao hou qiao rui hua, Meta-Burn EF, NKH477, Pashanabhedi. Traditional medical uses include the treatment of digestive disorders (stomachache, gastric and intestinal spasm, nausea, as a purgative), skin (burns, wounds, insect bites, allergies), infections (eg, syphilis, ringworm), and other conditions, including neck stiffness, and rheumatism, and as an emmenagogue and oral contraceptive. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. P. barbatus has been traditionally used as an emmenagogue and oral contraceptive.Lukhoba 2006, Almeida 2000 Forskolin delayed spontaneous meiotic progression in human oocytes in an in vitro fertility study.Shu 2008, None reported, but interactions with CYP3A-dependent drugs are theoretically possible. P. barbatus is a perennial herb in a large genus of mints. Coleus is a member of the Lamiaceae or Mint family and smells like camphor. Coleus blumei, Plectranthus scutellarioides), which is popular as a garden plant for its brightly colored foliage. (2019) list 294 species of Coleus, many transferred from Plectranthus. This information should not be used to decide whether or not to take this product. Quality clinical trials are lacking to substantiate claims made of the weight loss properties of forskolin, and clinical studies conducted with oral and inhaled forskolin in patients with asthma are limited. No changes in various metabolic markers or laboratory indices were found, except for changes in white blood count, serum calcium, ALT, and uric acid levels.Henderson 2005, Forskolin has been used in animal and limited clinical studies in glaucoma, with only temporary effects reported.Alasbahi 2010, In addition to smooth muscle relaxant properties, forskolin also exerts activity on inflammatory mediators, including interleukins and histamine, and on calcium ion influx, leading to its evaluation in asthma.Alasbahi 2010, Huerta 2010, In guinea pigs, forskolin blocked bronchospasm caused by inflammatory mediators (histamine, leukotriene-4) and antigens. Asthma: Oral forskolin has been studied using 10 mg daily over 2 to 6 months. Coleus and Solenostemon were sunk into Plectranthus, but recent phylogenetic analysis found Plectranthus to be paraphyletic with respect to other related genera in the subtribe Plectranthinae. Dr. Oz doesn't know it but he’s responsible for a lot of the emails I get. Plectranthus barbatus, also known by the synonym Coleus forskohlii is a tropical perennial plant related to the typical coleus species. This is only a brief summary of general information about this product. Potentiation of the antiplatelet effect of prostaglandins and aspirin has been demonstrated in vitro. Experimental studies on various cancer cell lines have shown synergistic effects of forskolin in upregulating cellular responses.Lekmine 2008, Watanabe 2004, Watanabe 2005, Tong 2004, Li 2006, Kim 2004 A protective effect against ionizing radiationSolovjeva 2009 and UBV-induced apoptosisPasseron 2009 has been shown in vitro. Although Coleus was previously sunk into Plectranthus, the original binomial was revived in a major study of the subtribe Plectranthinae in 2019. Information regarding safety and efficacy in pregnancy and lactation is lacking. [2], Coleus are cultivated as ornamental plants, particularly Coleus scutellarioides (syns. As a consequence of gluconeogenesis, interference with medicines used in diabetes may be expected.Alasbahi 2010, Forskolin-like substances have been identified in renal cyst fluid; therefore, forskolin should be avoided in patients with polycystic kidney disease.Putnam 2007, Large doses in mice have been reported to have a depressant action on the CNS, and perianal dermatitis has been reported with the use of whole plant extracts.Lukhoba 2006, Alasbahi 2010 Clinical trial data are generally lacking; however, a clinical trial found no changes in various metabolic markers or laboratory indices, except for changes in white blood count, serum calcium, ALT, and uric acid levels.Henderson 2005 Adverse events reported with the use of colforsin (a forskolin derivative) include tachycardia and arrhythmias.Alasbahi 2010, Hayashida 2001, Toxicology information is limited. 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